Bill Watterson's graduation speech, made to the graduating class at his alma mater, Kenyon College, in 1990.
I got a lot of inspiration from reading it today. Read it. It might change your life. Or it might just reinvigorate your life a little. Re-read it when you need it most.
If you don't know who Bill Watterson is, smack yourself in the head and go buy this. Better yet, buy this. I have it, and it's worth every penny.